The Complete Guide to Copper Peptides: GHK-Cu Explained

In 1973, biochemist Loren Pickart discovered a naturally occurring peptide in human plasma that had an extraordinary ability to stimulate tissue repair. He called it GHK — glycine-histidine-lysine. When bound to copper, it became GHK-Cu, and it turned out to be one of the most remarkable molecules in human biology.

What GHK-Cu Actually Does

GHK-Cu is a naturally occurring human peptide that declines dramatically with age. At age 20, plasma GHK-Cu levels are approximately 200 ng/mL. By age 60, they have dropped to 80 ng/mL — a 60% decline. This decline correlates closely with the visible signs of skin aging.

• —Stimulates collagen, elastin, and glycosaminoglycan synthesis
• —Activates over 4,000 human genes associated with skin repair and regeneration
• —Promotes angiogenesis (new blood vessel formation) for improved skin nutrition
• —Activates antioxidant and anti-inflammatory gene pathways
• —Stimulates the production of nerve growth factor for improved skin sensitivity
• —Promotes the removal of damaged proteins and scar tissue

GHK-Cu does not just slow aging. It actively reverses the molecular markers of skin aging at the genetic level.

How to Use Copper Peptides Correctly

The most important rule with copper peptides is: do not mix them with Vitamin C or strong acids at the same time. Copper ions can oxidize Vitamin C, reducing the efficacy of both. Use your copper peptide products in the evening and your Vitamin C in the morning for maximum benefit from both.

Copper peptides are also not compatible with retinol in the same application — the combination can cause irritation. If you use both, alternate evenings: copper peptides on Monday, Wednesday, Friday; retinol on Tuesday, Thursday.

Why We Built an Entire Collection Around GHK-Cu

The CU GLOW™ Collection — our Anti-Aging Serum, Eye Rescue Balm, and Moisturizing Face Cream — was developed to give copper peptide the full-routine treatment it deserves. Each product delivers GHK-Cu at its clinically validated concentration, in a base formulated to maximize penetration and stability. Together, they create a complete copper peptide ecosystem for the face.