18 Clinically Validated Peptide Actives · 5 Advanced Delivery Systems

Clinically validated
peptide complexes. One philosophy.

Eighteen distinct peptide actives. Each one clinically validated, encapsulated for sustained dermal delivery, and formulated at its minimum effective concentration. In 2026, VELPEPTIDE™ introduced five advanced delivery innovations — pH-triggered release, postbiotic amplification, Chronodyn® chronobiology, SPP deep-penetration conjugation, and waterless anhydrous formulation — to push every formula beyond what encapsulation alone can achieve.

Mimics collagen matrikines to signal fibroblasts via the TGF-β pathway. Stimulates type I & III collagen and fibronectin. Palmitoyl Tetrapeptide-7 simultaneously reduces pro-inflammatory IL-6 cytokines.

Simultaneously stimulates 6 key extracellular matrix proteins: collagen I, III, and IV, fibronectin, hyaluronic acid, and laminin-5. Comprehensive structural renewal beyond any single-target peptide.

Competes with SNAP-25 protein at the SNARE complex, disrupting acetylcholine release at the neuromuscular junction. The topical alternative to Botox.

Mimics endogenous enkephalins to reduce neuronal activity via a different mechanism to Argireline®. Combined, the dual-mechanism approach delivers longer-lasting expression line relaxation.

Extended 8-amino-acid analogue of SNAP-25. Inhibits SNARE complex formation more broadly than Argireline® alone. Targets forehead and crow's feet areas.

Synthetic analogue of waglerin-1 (Temple Viper venom). Acts as an acetylcholine receptor antagonist to reduce facial muscle contraction during sleep.

Reduces glycation-induced fluid accumulation and periorbital oedema. Inhibits angiotensin-converting enzyme to reduce vascular permeability under the eyes.

Mimics the structure of decorin — a protein that binds to collagen fibrils and controls fibril dimensions. Reorganises collagen fibres into thinner, more uniform bundles for improved skin cohesion.

Activates copper-dependent enzymes including Mn-SOD and lysyl oxidase, stimulating collagen, elastin, and glycosaminoglycan synthesis while neutralising UV-induced ROS. Liposomal encapsulation extends dermal delivery to 8–10 hours.

Patented bio-boosted brightening active by Givaudan Active Beauty. Inhibits MITF transcription — the master regulator of melanocyte differentiation — preventing tyrosinase from being produced before melanin synthesis begins. Activated by the skin’s own microbiome for progressive, sustained brightening. 4× more potent than Vitamin C. Globally approved across EU, US, India, China, Japan, and Korea.

TGF-β biomimetic signal peptide by DSM-Firmenich. Activates transforming growth factor-beta to stimulate collagen I and IV synthesis in fibroblasts, strengthening the dermal-epidermal junction. Formulated as a cyclodextrin complex (TFA-free grade) for sustained release. Used across VELVET CLEANSE™, VELVET TONE™, and VELVET BOOST™ to deliver collagen-building signal at every step of the ritual.

Signal peptide that activates protein kinase C to stimulate cell growth and proliferation in the dermis. Reduces UV-induced IL-6 release, providing anti-inflammatory protection against photodamage. Formulated in a phospholipid liposome base for 6–8 hour sustained dermal delivery. Used in VELVET FIRM™ as part of the five-peptide firming complex.

A two-component matrikine complex by Sederma (Croda). Palmitoyl Oligopeptide inhibits enzymes that degrade hemoglobin and bilirubin — the primary pigments responsible for dark under-eye circles. Palmitoyl Tetrapeptide-7 reduces IL-6 to decrease inflammation and puffiness. Together they reinforce firmness and tone of the periorbital zone. Formulated in liposome (part 1) and cyclodextrin (part 2) for dual sustained release.

High-performance tetrapeptide by Lipotec/Lubrizol that repairs the nuclear envelope by upregulating lamin A and downregulating progerin — the protein responsible for nuclear envelope degradation and skin sagging. Mimics the benefits of electrical microcurrent stimulation on skin. PFAS-free, fully EU Cosmetics Regulation compliant. Formulated as a polymeric nanoparticle for 8–12 hour sustained release. Used in VELVET NECK™ for the delicate neck and décolleté zone.

Signal peptide by Sederma (Croda) that stimulates hyaluronic acid and collagen synthesis specifically in the vermilion border of the lips. The thin lip stratum corneum (3–5 cells thick) makes it highly receptive to peptide delivery. Formulated in a phospholipid liposome for sustained release through the lip barrier. Provides progressive, non-injectable lip plumping without irritation. Used exclusively in VELVET LIP™.

High-performance tetrapeptide by Lucas Meyer Cosmetics (IFF) that clears progerin — the truncated Lamin A isoform that accumulates in fibroblast nuclei with age and causes nuclear envelope collapse, structural skin sagging, and loss of elasticity. Progerin is the same protein responsible for Hutchinson-Gilford Progeria Syndrome (accelerated aging). Progeline™ downregulates progerin expression by 30% in 28 days, restoring nuclear envelope integrity and fibroblast function. Globally compliant: EU Cosmetics Regulation, US CIR-reviewed, China IECIC-confirmed. Used exclusively in VELVET LONGEVITY™.

Patented tetrapeptide by Givaudan Active Beauty that reactivates the Wnt/β-catenin signalling pathway in epidermal stem cells — the same pathway that declines with age and causes the epidermis to thin, lose regenerative capacity, and become less resilient. By restoring Wnt/β-catenin activity, Reproage™ re-establishes epidermal stem cell self-renewal, increasing basal cell proliferation and epidermal thickness. Clinically proven to increase epidermal stem cell density. EU-approved, IECIC-confirmed. Used exclusively in VELVET LONGEVITY™.

Sirtuin-activating tetrapeptide by Lipotec/Lubrizol that directly activates SIRT1 and SIRT6 longevity genes in skin cells — the same sirtuins activated by caloric restriction and NAD+ supplementation in longevity research. SIRT1 activation triggers autophagy (cellular waste clearance) and DNA repair; SIRT6 activation improves metabolic efficiency and reduces glycation. Clinically proven to reduce wrinkle depth and improve skin density. The first topical cosmetic ingredient to activate both SIRT1 and SIRT6 simultaneously. EU-approved, CIR-reviewed, IECIC-confirmed. Used exclusively in VELVET LONGEVITY™.

Delivery Technology

Why encapsulation
changes everything.

A free peptide applied to skin lasts 1–2 hours before enzymatic degradation removes it. VELPEPTIDE™ uses three distinct encapsulation technologies to protect every active and extend its skin residence to 6–12 hours.

2026 Formulation Innovations

Five innovations
beyond encapsulation.

Encapsulation protects peptides from degradation. But protection alone is not enough. In 2026, VELPEPTIDE™ introduced five additional innovations that address when peptides are released, how deep they penetrate, what amplifies their receptor binding, how the skin's own circadian biology is synchronised to receive them, and how the formula base itself eliminates all in-formula degradation.

How each innovation works at the skin level

Diagram illustrates relative mechanism depth and action site. Not to anatomical scale. Sources: Sederma, Lipotec/Lubrizol, Evonik, Givaudan technical dossiers 2024.